|
Sign In to gain access to subscriptions and/or personal tools.
|
11(3):333-355 (2000) Crit Rev Oral Biol Med
© 2000 SAGE Publications
Biocompatibility of Resin-Modified Filling Materials
W. Geurtsen
Department of Conservative Dentistry & Periodontology, Medical University Hannover, Carl-Neuberg-Str. 1, D-30539 Hannover, Germany; Geurtsen.Werner{at}mh-Hannover.de
Increasing numbers of resin-based dental restorations have been placed over the past decade. During this same period, the public interest in the local and especially systemic adverse effects caused by dental materials has increased significantly It has been found that each resin-based material releases several components into the oral environment. In particular, the comonomer triethyleneglycol di-methacrylate (TEGDMA), and the 'hydrophilic' monomer, 2-hydroxy-ethyl-methacrylate (HEMA), are leached out from various composite resins and 'adhesive' materials (e.g., resin-modified glass-ionomer cements [GICs] and dentin adhesives) in considerable amounts during the first 24 hours after polymerization. Numerous unbound resin components may leach into saliva during the initial phase after polymerization, and later, due to degradation or erosion of the resinous restoration. Those substances may be systemically distributed and could potentially cause adverse systemic effects in patients. In addition, absorption of organic substances from unpolymerized material, through unprotected skin due to manual contact may pose a special risk for dental personnel. This is borne out by the increasing numbers of dental nurses, technicians, and dentists who present with allergic reactions to one or more resin components like HEMA glutaraldehyde ethyleneglycol di-methacrylate (EGDMA), and dibenzoyl peroxide (DPO). However, it must be emphasized that except for conventional composite resins, data reported on the release of substances from resin-based materials are scarce. There is very little reliable information with respect to the biological interactions between resin components and various tissues. Those interactions may be either protective, like absorption to dentin, or detrimental, e.g., inflammatory reactions of soft tissues Microbial effects have also been observed which may contribute indirectly to caries and irritation of the pulp. Therefore, it is critical, both for our patients and for the profession, that the biological effects of resin-based filling materials be clarified in the near future
Key Words: Resin-based materials • biocompatibility • leaching • adverse effects.
Critical Reviews in Oral Biology & Medicine, Vol. 11, No. 3,
333-355 (2000)
DOI: 10.1177/10454411000110030401
 CiteULike  Complore  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter What's this?
This article has been cited by other articles:
|
|
|
|
 
F. ANGIERO, G. FARRONATO, E. DESSY, S. MAGISTRO, R. SERAMONDI, D. FARRONATO, S. BENEDICENTI, and S. TETE
Evaluation of the Cytotoxic and Genotoxic Effects of Orthodontic Bonding Adhesives upon Human Gingival Papillae through Immunohistochemical Expression of p53, p63 and p16
Anticancer Res,
October 1, 2009;
29(10):
3983 - 3987.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Yamada, N. Kojima, A. Paranjpe, W. Att, H. Aita, A. Jewett, and T. Ogawa
N-acetyl Cysteine (NAC)-assisted Detoxification of PMMA Resin
Journal of Dental Research,
April 1, 2008;
87(4):
372 - 377.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Schweikl, G. Spagnuolo, and G. Schmalz
Genetic and Cellular Toxicology of Dental Resin Monomers
Journal of Dental Research,
October 1, 2006;
85(10):
870 - 877.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Final Report of the Safety Assessment of Methacrylate Ester Monomers Used in Nail Enhancement Products
International Journal of Toxicology,
September 1, 2005;
24(5_suppl):
53 - 100.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Lefeuvre, K. Bourd, M.-A. Loriot, M. Goldberg, P. Beaune, A. Perianin, and L. Stanislawski
TEGDMA Modulates Glutathione Transferase P1 Activity in Gingival Fibroblasts
Journal of Dental Research,
December 1, 2004;
83(12):
914 - 919.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Spagnuolo, C. Mauro, A. Leonardi, M. Santillo, R. Paterno, H. Schweikl, E.V. Avvedimento, and S. Rengo
NF-{kappa}B Protection against Apoptosis Induced by HEMA
Journal of Dental Research,
November 1, 2004;
83(11):
837 - 842.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Spagnuolo, K. Galler, G. Schmalz, C. Cosentino, S. Rengo, and H. Schweikl
Inhibition of Phosphatidylinositol 3-Kinase Amplifies TEGDMA-induced Apoptosis in Primary Human Pulp Cells
Journal of Dental Research,
September 1, 2004;
83(9):
703 - 707.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Wada, H. Tarumi, S. Imazato, M. Narimatsu, and S. Ebisu
In vitro Estrogenicity of Resin Composites
Journal of Dental Research,
March 1, 2004;
83(3):
222 - 226.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Schweikl, G. Schmalz, and W. Weinmann
The Induction of Gene Mutations and Micronuclei by Oxiranes and Siloranes in Mammalian Cells in vitro
Journal of Dental Research,
January 1, 2004;
83(1):
17 - 21.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Janke, N. von Neuhoff, B. Schlegelberger, G. Leyhausen, and W. Geurtsen
TEGDMA Causes Apoptosis in Primary Human Gingival Fibroblasts
Journal of Dental Research,
October 1, 2003;
82(10):
814 - 818.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Geurtsen
Toxicology of Dental Materials and 'Clinical Experience'
Journal of Dental Research,
July 1, 2003;
82(7):
500 - 500.
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Geurtsen and G. Leyhausen
Concise Review Biomaterials & Bioengineering: Chemical-Biological Interactions of the Resin Monomer Triethyleneglycol-dimethacrylate (TEGDMA)
Journal of Dental Research,
December 1, 2001;
80(12):
2046 - 2050.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. Engelmann, G. Leyhausen, D. Leibfritz, and W. Geurtsen
Metabolic Effects of Dental Resin Components in vitro Detected by NMR Spectroscopy
Journal of Dental Research,
March 1, 2001;
80(3):
869 - 875.
[Abstract]
[PDF]
|
|
|
|
|
