Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Critical Reviews in Oral Biology & Medicine
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Iida, K.
Right arrow Articles by Nishimura, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?
13(1):35-50 (2002)     Crit Rev Oral Biol Med
© 2002 International and American Associations for Dental Research

GENE EXPRESSION PROFILING BY DNA MICROARRAY TECHNOLOGY

Keisuke Iida and Ichiro Nishimura*

The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, Biomaterials and Hospital Dentistry, UCLA School of Dentistry, Box 951668, CHS B3-082, Los Angeles, California 90095-1668, USA;

Correspondence: * corresponding author, ichiron{at}dent.ucla.edu

Methods in molecular and genetic biology have provided important clues to elucidate the complex mechanisms of oral and craniofacial development and pathogenesis of diseases. It has become increasingly clear that a biological phenotype is a result of multiple factors involving a large number of regulatory genes, while a single nucleotide mutation can cause various degrees of oral and craniofacial abnormalities. These oral and craniofacial problems often present a challenge to the molecular screening process. Recent advances in microarray-based technologies allow for large-scale gene expression analysis in a single experiment, which have been applied to genome-wide assays, mutational analysis, drug discovery, developmental biology, and molecular analysis of various diseases. This review introduces the basic principle and some modifications of techniques and materials used in microarray technology, as well as currently available microarray data analysis strategies. Microarray technology can be applied to the soon-to-be-available human genome database and will be a powerful research tool for those inquiring into specific problems associated with oral and craniofacial biology.

Key Words: DNA microarray • oligonucleotide • gene expression • oral biology • post-genomics

Critical Reviews in Oral Biology & Medicine, Vol. 13, No. 1, 35-50 (2002)
DOI: 10.1177/154411130201300105
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
H. Egusa, F. E. Schweizer, C.-C. Wang, Y. Matsuka, and I. Nishimura
Neuronal Differentiation of Bone Marrow-derived Stromal Stem Cells Involves Suppression of Discordant Phenotypes through Gene Silencing
J. Biol. Chem., June 24, 2005; 280(25): 23691 - 23697.
[Abstract] [Full Text] [PDF]

Home page
 CROBMHome page
I. Nishimura, T. A. Drake, A. J. Lusis, K. M. Lyons, J. H. Nadeau, and J. Zernik
ENU LARGE-SCALE MUTAGENESIS AND QUANTITATIVE TRAIT LINKAGE (QTL) ANALYSIS IN MICE: NOVEL TECHNOLOGIES FOR SEARCHING POLYGENETIC DETERMINANTS OF CRANIOFACIAL ABNORMALITIES
Critical Reviews in Oral Biology & Medicine, September 1, 2003; 14(5): 320 - 330.
[Abstract] [Full Text] [PDF]