This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Kaufman, E. Articles by Lamster, I. B. Search for Related Content PubMed PubMed Citation Social Bookmarking                         What's this?

THE DIAGNOSTIC APPLICATIONS OF SALIVA— A REVIEW

¹ Division of Periodontics, Columbia University, School of Dental and Oral Surgery, 630 West 168th Street, PH-7E, Room 110, New York, NY 10032, USA;

Correspondence: ^* corresponding author, ek183{at}columbia.edu

This review examines the diagnostic application of saliva for systemic diseases. As a diagnostic fluid, saliva offers distinctive advantages over serum because it can be collected non-invasively by individuals with modest training. Furthermore, saliva may provide a cost-effective approach for the screening of large populations. Gland-specific saliva can be used for diagnosis of pathology specific to one of the major salivary glands. Whole saliva, however, is most frequently used for diagnosis of systemic diseases, since it is readily collected and contains serum constituents. These constituents are derived from the local vasculature of the salivary glands and also reach the oral cavity via the flow of gingival fluid. Analysis of saliva may be useful for the diagnosis of hereditary disorders, autoimmune diseases, malignant and infectious diseases, and endocrine disorders, as well as in the assessment of therapeutic levels of drugs and the monitoring of illicit drug use.

Key Words: Saliva • diagnosis • systemic • disease • drug • hormone

Critical Reviews in Oral Biology & Medicine, Vol. 13, No. 2, 197-212 (2002)
DOI: 10.1177/154411130201300209


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				P. N. Floriano, N. Christodoulides, C. S. Miller, J. L. Ebersole, J. Spertus, B. G. Rose, D. F. Kinane, M. J. Novak, S. Steinhubl, S. Acosta, et al. Use of Saliva-Based Nano-Biochip Tests for Acute Myocardial Infarction at the Point of Care: A Feasibility Study Clin. Chem., August 1, 2009; 55(8): 1530 - 1538. [Abstract] [Full Text] [PDF]

				P. Wood Salivary steroid assays - research or routine? Ann Clin Biochem, May 1, 2009; 46(3): 183 - 196. [Abstract] [Full Text] [PDF]

				T. M. Blicharz, D. M. Rissin, M. Bowden, R. B. Hayman, C. DiCesare, J. S. Bhatia, N. Grand-Pierre, W. L. Siqueira, E. J. Helmerhorst, J. Loscalzo, et al. Use of Colorimetric Test Strips for Monitoring the Effect of Hemodialysis on Salivary Nitrite and Uric Acid in Patients with End-Stage Renal Disease: A Proof of Principle Clin. Chem., September 1, 2008; 54(9): 1473 - 1480. [Abstract] [Full Text] [PDF]

				C.W. Bassim, R.S. Redman, D.J. DeNucci, K.L. Becker, and E.S. Nylen Salivary Procalcitonin and Periodontitis in Diabetes Journal of Dental Research, July 1, 2008; 87(7): 630 - 634. [Abstract] [Full Text] [PDF]

				N. O. Wilson, A. A. Adjei, W. Anderson, S. Baidoo, and J. K. Stiles Detection of Plasmodium falciparum Histidine-rich Protein II in Saliva of Malaria Patients Am J Trop Med Hyg, May 1, 2008; 78(5): 733 - 735. [Abstract] [Full Text] [PDF]

				Z. Hu, B. G. Zimmermann, H. Zhou, J. Wang, B. S. Henson, W. Yu, D. Elashoff, G. Krupp, and D. T. Wong Exon-Level Expression Profiling: A Comprehensive Transcriptome Analysis of Oral Fluids Clin. Chem., May 1, 2008; 54(5): 824 - 832. [Abstract] [Full Text] [PDF]

				K. L. Scolaro, K. B. Lloyd, and K. L. Helms Devices for home evaluation of women's health concerns Am. J. Health Syst. Pharm., February 15, 2008; 65(4): 299 - 314. [Abstract] [Full Text] [PDF]

				A. T. Vernillo and A. L. Caplan Routine HIV Testing in Dental Practice: Can We Cross the Rubicon? J Dent Educ., December 1, 2007; 71(12): 1534 - 1539. [Abstract] [Full Text] [PDF]

				M. C Walsh, L. Brennan, J P. G Malthouse, H. M Roche, and M. J Gibney Effect of acute dietary standardization on the urinary, plasma, and salivary metabolomic profiles of healthy humans. Am. J. Clinical Nutrition, September 1, 2006; 84(3): 531 - 539. [Abstract] [Full Text] [PDF]

				N. J. Park, Y. Li, T. Yu, B. M.N. Brinkman, and D. T. Wong Characterization of RNA in Saliva Clin. Chem., June 1, 2006; 52(6): 988 - 994. [Abstract] [Full Text] [PDF]

				C. S. Miller, C. P. King Jr., M. C. Langub, R. J. Kryscio, and M. V. Thomas Salivary biomarkers of existing periodontal disease: A cross-sectional study J Am Dent Assoc, March 1, 2006; 137(3): 322 - 329. [Abstract] [Full Text] [PDF]

				C. Streckfus and L. Bigler The Use of Soluble, Salivary c-erbB-2 for the Detection and Post-operative Follow-up of Breast Cancer in Women: The Results of a Five-year Translational Research Study Advances in Dental Research, June 1, 2005; 18(1): 17 - 24. [Full Text] [PDF]