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CHEMOTACTIC SIGNALING PATHWAYS IN NEUTROPHILS: FROM RECEPTOR TO ACTIN ASSEMBLY

Hematology Division, Harvard Medical School, Brigham and Women's Hospital, LMRC 301, 221 Longwood Avenue, Boston, MA 02115;

Correspondence: ^* current address, corresponding author, University of Toronto, Room 239 Fitzgerald Building, 150 College Street, Toronto M5S 3E2, Canada; michael.glogauer{at}utoronto.ca

In this review, we present an overview of the signaling elements between neutrophil chemotactic receptors and the actin cytoskeleton that drives cell motility. From receptor-ligand interactions, activation of heterotrimeric G-proteins, their downstream effectors PLC and PI-3 kinase, the activation of small GTPases of the Rho family, and their regulation of particular cytoskeletal regulatory proteins, we describe pathways specific to the chemotaxing neutrophil and elements documented to be important for neutrophil function.

Key Words: Neutrophil • chemotaxis • actin • cytoskeleton

Critical Reviews in Oral Biology & Medicine, Vol. 13, No. 3, 220-228 (2002)
DOI: 10.1177/154411130201300302


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