This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Vissink, A. Articles by Coppes, R.P. Search for Related Content PubMed PubMed Citation Social Bookmarking                         What's this?

ORAL SEQUELAE OF HEAD AND NECK RADIOTHERAPY

¹ Department of Oral and Maxillofacial Surgery
² Department of Radiotherapy, University Hospital, PO Box 30.001, 9700 RB Groningen, the Netherlands;
³ Department of Radiation and Stress Cell Biology, University of Groningen, Ant. Deusinglaan 1, 9713 AV Groningen, the Netherlands

Correspondence: *corresponding author, A.Vissink{at}kchir.azg.nl

In addition to anti-tumor effects, ionizing radiation causes damage in normal tissues located in the radiation portals. Oral complications of radiotherapy in the head and neck region are the result of the deleterious effects of radiation on, e.g., salivary glands, oral mucosa, bone, dentition, masticatory musculature, and temporomandibular joints. The clinical consequences of radiotherapy include mucositis, hyposalivation, taste loss, osteoradionecrosis, radiation caries, and trismus. Mucositis and taste loss are reversible consequences that usually subside early post-irradiation, while hyposalivation is normally irreversible. Furthermore, the risk of developing radiation caries and osteoradionecrosis is a life-long threat. All these consequences form a heavy burden for the patients and have a tremendous impact on their quality of life during and after radiotherapy. In this review, the radiation-induced changes in healthy oral tissues and the resulting clinical consequences are discussed.

Key Words: Radiotherapy • mucositis • xerostomia • caries • osteoradionecrosis

Critical Reviews in Oral Biology & Medicine, Vol. 14, No. 3, 199-212 (2003)
DOI: 10.1177/154411130301400305


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				M. J. Oudhoff, K. L. Kroeze, K. Nazmi, P. A. M. van den Keijbus, W. van 't Hof, M. Fernandez-Borja, P. L. Hordijk, S. Gibbs, J. G. M. Bolscher, and E. C. I. Veerman Structure-activity analysis of histatin, a potent wound healing peptide from human saliva: cyclization of histatin potentiates molar activity 1000-fold FASEB J, November 1, 2009; 23(11): 3928 - 3935. [Abstract] [Full Text] [PDF]

				N. R. Rigual, K. Thankappan, M. Cooper, M. A. Sullivan, T. Dougherty, S. R. Popat, T. R. Loree, M. A. Biel, and B. Henderson Photodynamic Therapy for Head and Neck Dysplasia and Cancer Arch Otolaryngol Head Neck Surg, August 1, 2009; 135(8): 784 - 788. [Abstract] [Full Text] [PDF]

				I. M.A. Lombaert, J. F. Brunsting, P. K. Wierenga, H. H. Kampinga, G. de Haan, and R. P. Coppes Cytokine Treatment Improves Parenchymal and Vascular Damage of Salivary Glands after Irradiation Clin. Cancer Res., December 1, 2008; 14(23): 7741 - 7750. [Abstract] [Full Text] [PDF]

				C-Y HSIUNG, E-Y HUANG, H-M TING, and H-Y HUANG Intensity-modulated radiotherapy for nasopharyngeal carcinoma: the reduction of radiation-induced trismus Br. J. Radiol., October 1, 2008; 81(970): 809 - 814. [Abstract] [Full Text] [PDF]

				A. P. Cotrim, F. Hyodo, K.-I. Matsumoto, A. L. Sowers, J. A. Cook, B. J. Baum, M. C. Krishna, and J. B. Mitchell Differential Radiation Protection of Salivary Glands versus Tumor by Tempol with Accompanying Tissue Assessment of Tempol by Magnetic Resonance Imaging Clin. Cancer Res., August 15, 2007; 13(16): 4928 - 4933. [Abstract] [Full Text] [PDF]

				H.-J. Lee, Y.-J. Lee, H.-C. Kwon, S. Bae, S.-H. Kim, J.-J. Min, C.-K. Cho, and Y.-S. Lee Radioprotective Effect of Heat Shock Protein 25 on Submandibular Glands of Rats Am. J. Pathol., November 1, 2006; 169(5): 1601 - 1611. [Abstract] [Full Text] [PDF]

				P.L. Sandow, M. Hejrat-Yazdi, and M.W. Heft Taste Loss and Recovery Following Radiation Therapy Journal of Dental Research, July 1, 2006; 85(7): 608 - 611. [Abstract] [Full Text] [PDF]

				I. M.A. Lombaert, P. K. Wierenga, T. Kok, H. H. Kampinga, G. deHaan, and R. P. Coppes Mobilization of bone marrow stem cells by granulocyte colony-stimulating factor ameliorates radiation-induced damage to salivary glands. Clin. Cancer Res., March 15, 2006; 12(6): 1804 - 1812. [Abstract] [Full Text] [PDF]

				A. P. Cotrim, A. L. Sowers, B. M. Lodde, J. M. Vitolo, A. Kingman, A. Russo, J. B. Mitchell, and B. J. Baum Kinetics of Tempol for Prevention of Xerostomia Following Head and Neck Irradiation in a Mouse Model Clin. Cancer Res., October 15, 2005; 11(20): 7564 - 7568. [Abstract] [Full Text] [PDF]

				S. W. Redding Cancer Therapy-Related Oral Mucositis J Dent Educ., August 1, 2005; 69(8): 919 - 929. [Abstract] [Full Text] [PDF]

				J. M. Vitolo, A. P. Cotrim, A. L. Sowers, A. Russo, R. B. Wellner, S. R. Pillemer, J. B. Mitchell, and B. J. Baum The Stable Nitroxide Tempol Facilitates Salivary Gland Protection during Head and Neck Irradiation in a Mouse Model Clin. Cancer Res., March 1, 2004; 10(5): 1807 - 1812. [Abstract] [Full Text] [PDF]

				A. Vissink, F.R. Burlage, F.K.L. Spijkervet, J. Jansma, and R.P. Coppes PREVENTION AND TREATMENT OF THE CONSEQUENCES OF HEAD AND NECK RADIOTHERAPY Critical Reviews in Oral Biology & Medicine, May 1, 2003; 14(3): 213 - 225. [Abstract] [Full Text] [PDF]