This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Teng, Y.-T. A. Search for Related Content PubMed PubMed Citation Social Bookmarking                         What's this?

THE ROLE OF ACQUIRED IMMUNITY AND PERIODONTAL DISEASE PROGRESSION

^* Division of Periodontics, School of Dentistry, and Department of Microbiology & Immunology, Faculty of Medicine & Dentistry, the University of Western Ontario, London, Ontario N6A 5C1, Canada; Lawson Health Research Institute, London Health Sciences Centre, London, Ontario N6A 4G5; and Division of Periodontics, Eastman Dental Clinic, Center for Oral Biology, and Dept. of Microbiology and Immunology, School of Medicine & Dentistry, University of Rochester, NY, USA 14620-2989;

Correspondence: ^* addresses for correspondence, yateng{at}uwo.ca and andy_teng{at}urmc.rochester.edu

Our understanding of the pathogenesis in human periodontal diseases is limited by the lack of specific and sensitive tools or models to study the complex microbial challenges and their interactions with the host’s immune system. Recent advances in cellular and molecular biology research have demonstrated the importance of the acquired immune system not only in fighting the virulent periodontal pathogens but also in protecting the host from developing further devastating conditions in periodontal infections. The use of genetic knockout and immunodeficient mouse strains has shown that the acquired immune response—in particular, CD4⁺ T-cells—plays a pivotal role in controlling the ongoing infection, the immune/inflammatory responses, and the subsequent host’s tissue destruction. In particular, studies of the pathogen-specific CD4⁺ T-cell-mediated immunity have clarified the roles of: (i) the relative diverse immune repertoire involved in periodontal pathogenesis, (ii) the contribution of pathogen-associated Th1-Th2 cytokine expressions in periodontal disease progression, and (iii) micro-organism-triggered periodontal CD4⁺ T-cell-mediated osteoclastogenic factor, ‘RANK-L’, which is linked to the induction of alveolar bone destruction in situ. The present review will focus on some recent advances in the acquired immune responses involving B-cells, CD8⁺ T-cells, and CD4⁺ T-cells in the context of periodontal disease progression. New approaches will further facilitate our understanding of their underlying molecular mechanisms that may lead to the development of new treatment modalities for periodontal diseases and their associated complications.

Abbreviations used in the paper are as follows: Antibody, Ab; antigen, Ag; antigen-presenting cells, APC; Actinobacillus actinomycetemcomitans, A. actinomycetemcomitans or Aa; β₂-microglobulin, β₂m; cytotoxic CD8⁺ β T-lymphocytes, CTL; dendritic cells, DC; delayed-type hypersensitivity, DTH; immunoglobulin, Ig; Fc receptor, Fc-R; interferon-, IFN-; receptor activator of NF-B ligand, RANK-L; molecular weight, MW; Porphyromonas gingivalis, P. gingivalis or Pg; localized juvenile periodontitis, LJP; lipopolysaccharide, LPS; mouse mammalian tumor virus, MMTV; non-obese diabetic and severe combined immunodeficiency mice, NOD/SCID mice; osteoclast, OC; T-helper cells, Th; superantigen, SAg; transforming growth factor-β, TGF-β; secretory-IgA, s-IgA; T-cell receptor, TCR; T cytotoxic-1 cells, Tc1; and T cytotoxic-2 cells, Tc2.

Key Words: Human periodontitis • acquired immunity • CD4⁺ T-cell immune repertoire • type-1 vs type-2 cytokines • osteoclastogenesis • RANK-L

Critical Reviews in Oral Biology & Medicine, Vol. 14, No. 4, 237-252 (2003)
DOI: 10.1177/154411130301400402


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				H. Ohyama, N. Kato-Kogoe, A. Kuhara, F. Nishimura, K. Nakasho, K. Yamanegi, N. Yamada, M. Hata, J. Yamane, and N. Terada The Involvement of IL-23 and the Th17 Pathway in Periodontitis Journal of Dental Research, July 1, 2009; 88(7): 633 - 638. [Abstract] [Full Text] [PDF]

				J. R. Kiesel, Z. S. Buchwald, and R. Aurora Cross-Presentation by Osteoclasts Induces FoxP3 in CD8+ T Cells J. Immunol., May 1, 2009; 182(9): 5477 - 5487. [Abstract] [Full Text] [PDF]

				S. Nares, N. M. Moutsopoulos, N. Angelov, Z. G. Rangel, P. J. Munson, N. Sinha, and S. M. Wahl Rapid Myeloid Cell Transcriptional and Proteomic Responses to Periodontopathogenic Porphyromonas gingivalis Am. J. Pathol., April 1, 2009; 174(4): 1400 - 1414. [Abstract] [Full Text] [PDF]

				J. J. Yu, M. J. Ruddy, H. R. Conti, K. Boonanantanasarn, and S. L. Gaffen The Interleukin-17 Receptor Plays a Gender-Dependent Role in Host Protection against Porphyromonas gingivalis-Induced Periodontal Bone Loss Infect. Immun., September 1, 2008; 76(9): 4206 - 4213. [Abstract] [Full Text] [PDF]

				H. Sasaki, N. Suzuki, R. Kent Jr., N. Kawashima, J. Takeda, and P. Stashenko T Cell Response Mediated by Myeloid Cell-Derived IL-12 Is Responsible for Porphyromonas gingivalis-Induced Periodontitis in IL-10-Deficient Mice J. Immunol., May 1, 2008; 180(9): 6193 - 6198. [Abstract] [Full Text] [PDF]

				Q. Luan, T. Desta, L. Chehab, V.J. Sanders, J. Plattner, and D.T. Graves Inhibition of Experimental Periodontitis by a Topical Boron-based Antimicrobial Journal of Dental Research, February 1, 2008; 87(2): 148 - 152. [Abstract] [Full Text] [PDF]

				J. J. Yu, M. J. Ruddy, G. C. Wong, C. Sfintescu, P. J. Baker, J. B. Smith, R. T. Evans, and S. L. Gaffen An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals Blood, May 1, 2007; 109(9): 3794 - 3802. [Abstract] [Full Text] [PDF]

				M. Alnaeeli, J. M. Penninger, and Y.-T. A. Teng Immune Interactions with CD4+ T Cells Promote the Development of Functional Osteoclasts from Murine CD11c+ Dendritic Cells. J. Immunol., September 1, 2006; 177(5): 3314 - 3326. [Abstract] [Full Text] [PDF]

				X. Zhang and Y.-T. A. Teng Interleukin-10 Inhibits Gram-Negative-Microbe-Specific Human Receptor Activator of NF-{kappa}B Ligand-Positive CD4+-Th1-Cell- Associated Alveolar Bone Loss In Vivo. Infect. Immun., August 1, 2006; 74(8): 4927 - 4931. [Abstract] [Full Text] [PDF]

				C.W. Cutler and R. Jotwani Dendritic Cells at the Oral Mucosal Interface Journal of Dental Research, August 1, 2006; 85(8): 678 - 689. [Abstract] [Full Text] [PDF]

				C. W. Leone, H. Bokhadhoor, D. Kuo, T. Desta, J. Yang, M. F. Siqueira, S. Amar, and D. T. Graves Immunization Enhances Inflammation and Tissue Destruction in Response to Porphyromonas gingivalis Infect. Immun., April 1, 2006; 74(4): 2286 - 2292. [Abstract] [Full Text] [PDF]

				Y.-T.A. Teng Protective and Destructive Immunity in the Periodontium: Part 1--Innate and Humoral Immunity and the Periodontium Journal of Dental Research, March 1, 2006; 85(3): 198 - 208. [Abstract] [Full Text] [PDF]

				Y.-T.A. Teng Protective and Destructive Immunity in the Periodontium: Part 2--T-cell-mediated Immunity in the Periodontium Journal of Dental Research, March 1, 2006; 85(3): 209 - 219. [Abstract] [Full Text] [PDF]

				Y.-T. A. Teng, D. Mahamed, and B. Singh Gamma Interferon Positively Modulates Actinobacillus actinomycetemcomitans-Specific RANKL+ CD4+ Th-Cell-Mediated Alveolar Bone Destruction In Vivo Infect. Immun., June 1, 2005; 73(6): 3453 - 3461. [Abstract] [Full Text] [PDF]

				P. Valverde, T. Kawai, and M.A. Taubman Potassium Channel-blockers as Therapeutic Agents to Interfere with Bone Resorption of Periodontal Disease Journal of Dental Research, June 1, 2005; 84(6): 488 - 499. [Abstract] [Full Text] [PDF]

				D. A. Mahamed, A. Marleau, M. Alnaeeli, B. Singh, X. Zhang, J. M. Penninger, and Y.-T. A. Teng G(-) Anaerobes-Reactive CD4+ T-Cells Trigger RANKL-Mediated Enhanced Alveolar Bone Loss in Diabetic NOD Mice Diabetes, May 1, 2005; 54(5): 1477 - 1486. [Abstract] [Full Text] [PDF]

				A. Mainnemare, B. Megarbane, A. Soueidan, A. Daniel, and I.L.C. Chapple Hypochlorous Acid and Taurine-N-Monochloramine in Periodontal Diseases Journal of Dental Research, November 1, 2004; 83(11): 823 - 831. [Abstract] [Full Text] [PDF]