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Critical Reviews in Oral Biology & Medicine
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15(5):298-307 (2004)     Crit Rev Oral Biol Med
© 2004 International and American Associations for Dental Research

SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTION: INSIGHTS INTO THE MOLECULAR BASIS OF ORAL CANCER

H. Siavash1,2,*, N.G. Nikitakis2,3 and J.J. Sauk2,3

1 Department of Biomedical Sciences and
2 Department of Diagnostic Sciences and Pathology, University of Maryland, Dental School, 666 West Baltimore Street, Room 4-C-02, Baltimore, MD 21201; and
3 Greenebaum Cancer Center, University of Maryland, Baltimore, MD 21201;

Correspondence: * corresponding author, hsiav001{at}umaryland.edu

Recent efforts on developing more direct and effective targets for cancer therapy have revolved around a family of transcription factors known as STATs (signal transducers and activators of transcription). STAT proteins are latent cytoplasmic transcription factors that become activated in response to extracellular signaling proteins. STAT proteins have been convincingly reported to possess oncogenic properties in a plethora of human cancers, including oral and oropharyngeal cancer. Signal transduction pathways mediated by these oncogenic transcription factors and their regulation in oral cancer are the focus of this review.

Key Words: Signal transducer and activator of transcription (STAT) • oral squamous cell carcinoma (SCC) • signal transduction • oncogene

Critical Reviews in Oral Biology & Medicine, Vol. 15, No. 5, 298-307 (2004)
DOI: 10.1177/154411130401500505
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