Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
Critical Reviews in Oral Biology & Medicine
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Diewert, V. M.
Right arrow Articles by Wang, K.-Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
4(1):111-130 (1992)     Crit Rev Oral Biol Med
© 1992 SAGE Publications

Recent Advances in Primary Palate and Midface Morphogenesis Research

Virginia M. Diewert

Departments of Clinical Dental Sciences, and Oral Biology, University of British Columbia, Vancouver, British Columbia

Kang-Yee Wang

Departments of Clinical Dental Sciences, and Oral Biology, University of British Columbia, Vancouver, British Columbia

During the sixth week of human development, the primary palate develops as facial prominences enlarge around the nasal pits to form the premaxillary region. Growth of craniofacial components changes facial morphology and affects the extent of contact between the facial prominences. Our recent studies have focused on developing methods to analyze growth of the primary palate and the craniofacial complex to define morphological phases of normal development and to determine alterations leading to cleft lip malformation. Analysis of human embryos in the Carnegie Embryology Collection and mouse embryos of cleft lip and noncleft strains showed that human and mouse embryos have similar phases of primary palate development: first, an epithelial seam, the nasal fin, forms; then a mesenchymal bridge develops through the nasal fin and enlarges rapidly. A robust mesenchymal bridge must form between the facial prominences before advancing midfacial growth patterns tend to separate the facial components as the medial nasal region narrows and elongates, the nasal pits narrow, and the primary choanae (posterior nares) open posterior to the primary palate. In mouse strains with cleft lip gene, maxillary growth, nasal fin formation, and mesenchymal replacement of the nasal fin were all delayed compared with noncleft strains of mice. Successful primary palate formation involves a sequence of local cellular events that are closely timed with spatial changes associated with craniofacial growth that must occur within a critical developmental period.

Key Words: embryology • craniofacial growth • palatogenesis • cleft palate.

Critical Reviews in Oral Biology & Medicine, Vol. 4, No. 1, 111-130 (1992)
DOI: 10.1177/10454411920040010201
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Toxicol SciHome page
R. J. Lipinski, P. R. Hutson, P. W. Hannam, R. J. Nydza, I. M. Washington, R. W. Moore, G. G. Girdaukas, R. E. Peterson, and W. Bushman
Dose- and Route-Dependent Teratogenicity, Toxicity, and Pharmacokinetic Profiles of the Hedgehog Signaling Antagonist Cyclopamine in the Mouse
Toxicol. Sci., July 1, 2008; 104(1): 189 - 197.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
V. Dupe, N. Matt, J.-M. Garnier, P. Chambon, M. Mark, and N. B. Ghyselinck
A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment
PNAS, November 25, 2003; 100(24): 14036 - 14041.
[Abstract] [Full Text] [PDF]

Home page
 JDRHome page
A. Iamaroon, B. Tait, and V.M. Diewert
Cell Proliferation and Expression of EGF, TGF-{alpha}, and EGF Receptor in the Developing Primary Palate
Journal of Dental Research, August 1, 1996; 75(8): 1534 - 1539.
[Abstract] [PDF]

Home page
 CROBMHome page
M.C. Johnston and P.T. Bronsky
Prenatal Craniofacial Development: New Insights On Normal and Abnormal Mechanisms
Critical Reviews in Oral Biology & Medicine, January 1, 1995; 6(1): 25 - 79.
[Abstract] [Full Text] [PDF]

Home page
 CROBMHome page
M.C. Johnston and P.T. Bronsky
Prenatal Craniofacial Development: New Insights on Normal and Abnormal Mechanisms
Critical Reviews in Oral Biology & Medicine, January 1, 1995; 6(4): 368 - 422.
[Abstract] [Full Text] [PDF]