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4(2):159-176 (1993) Crit Rev Oral Biol Med
© 1993 SAGE Publications
Virulence Factors of Mutans Streptococci: Role of Molecular Genetics
Howard K. Kuramitsu
Departments of Pediatric Dentistry and Microbiology, University of Texas Health Science Center, San Antonio, TX
Biochemical approaches were utilized initially to identify the virulence factors of the mutans streptococci (primarily Streptococcus mutans and S. sobrinu). Traditional mutant analysis of these organisms further suggested the important role of several of these factors in cariogenicity. However, because these mutations were not clearly defined, the utilization of cloned genes was necessary to verify their significance. The introduction of molecular genetic approaches for characterizing these factors has led not only to a clearer understanding of the role of these virulence factors in cariogenicity but has also suggested some novel approaches for reducing further the incidence of dental caries.
Key Words: Streptococcus mutans • S. sobrinus • molecular genetics • adhesins • sucrose-enhanced colonization of teeth • glucosyltransferases.
Critical Reviews in Oral Biology & Medicine, Vol. 4, No. 2,
159-176 (1993)
DOI: 10.1177/10454411930040020201
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