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Critical Reviews in Oral Biology & Medicine
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4(2):197-250 (1993)     Crit Rev Oral Biol Med
© 1993 SAGE Publications

Reviews

Matrix Metalloproteinases: A Review

H. Birkedal-Hansen

Department of Oral Biology, University of Alabama at Birmingham, Birmingham, Alabama, Research Center in Oral Biology, University of Alabama at Birmingham, Birmingham, Alabama

W.G.I. Moore

Department of Oral Biology, University of Alabama at Birmingham, Birmingham, Alabama

M.K. Bodden

Department of Restorative Dentistry, University of Alabama at Birmingham, Birmingham, Alabama, Department of Pathology, , University of Alabama at Birmingham, Birmingham, Alabama

L.J. Windsor

Department of Biochemistry, University of Alabama at Birmingham, Birmingham, Alabama

B. Birkedal-Hansen

Department of Diagnostic Sciences, , University of Alabama at Birmingham, Birmingham, Alabama

A. DeCarlo

Department of Periodontics, University of Alabama School of Dentistry, , University of Alabama at Birmingham, Birmingham, Alabama, Department of Biochemistry, University of Alabama at Birmingham, Birmingham, Alabama

J.A. Engler

Research Center in Oral Biology, University of Alabama at Birmingham, Birmingham, Alabama, Department of Biochemistry, University of Alabama at Birmingham, Birmingham, Alabama

Matrix metalloproteinases (MMPs) are a family of nine or more highly homologous Zn++endopeptidases that collectively cleave most if not all of the constituents of the extracellular matrix. The present review discusses in detail the primary structures and the overlapping yet distinct substrate specificities of MMPs as well as the mode of activation of the unique MMP precursors. The regulation of MMP activity at the transcriptional level and at the extracellular level (precursor activation, inhibition of activated, mature enzymes) is also discussed. A final segment of the review details the current knowledge of the involvement of MMP in specific developmental or pathological conditions, including human periodontal diseases.

Key Words: matrix metalloproteinases • extracellular matrix • collagenase • regulation of tissue destruction • human periodontal diseases.

Critical Reviews in Oral Biology & Medicine, Vol. 4, No. 2, 197-250 (1993)
DOI: 10.1177/10454411930040020401
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Acute Effects of PGF2{alpha} on MMP-2 Secretion from Human Ciliary Muscle Cells: A PKC- and ERK-Dependent Process
Invest. Ophthalmol. Vis. Sci., May 1, 2005; 46(5): 1706 - 1713.
[Abstract] [Full Text] [PDF]

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 Hum ReprodHome page
M. Tang, Y. Xu, J. Julian, D. Carson, and S. Tabibzadeh
Lefty is expressed in mouse endometrium in estrous cycle and peri-implantation period
Hum. Reprod., April 1, 2005; 20(4): 872 - 880.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
J. Cao, A. Rehemtulla, M. Pavlaki, P. Kozarekar, and C. Chiarelli
Furin Directly Cleaves proMMP-2 in the trans-Golgi Network Resulting in a Nonfunctioning Proteinase
J. Biol. Chem., March 25, 2005; 280(12): 10974 - 10980.
[Abstract] [Full Text] [PDF]

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 Eur Respir JHome page
D. Iglesias, J. Alegre, C. Aleman, E. Ruiz, T. Soriano, L. I. Armadans, R. M. Segura, A. Angles, J. Monasterio, and T. Fernandez de Sevilla
Metalloproteinases and tissue inhibitors of metalloproteinases in exudative pleural effusions
Eur. Respir. J., January 1, 2005; 25(1): 104 - 109.
[Abstract] [Full Text] [PDF]

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 Physiol. Rev.Home page
A. C. Newby
Dual Role of Matrix Metalloproteinases (Matrixins) in Intimal Thickening and Atherosclerotic Plaque Rupture
Physiol Rev, January 1, 2005; 85(1): 1 - 31.
[Abstract] [Full Text] [PDF]

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 J BiochemHome page
T. Aoki, D. Sato, Y. Li, T. Takino, H. Miyamori, and H. Sato
Cleavage of Apolipoprotein E by Membrane-Type Matrix Metalloproteinase-1 Abrogates Suppression of Cell Proliferation
J. Biochem., January 1, 2005; 137(1): 95 - 99.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
Y. Jia, Z.-Z. Zeng, S. M. Markwart, K. F. Rockwood, K. M. W. Ignatoski, S. P. Ethier, and D. L. Livant
Integrin Fibronectin Receptors in Matrix Metalloproteinase-1-Dependent Invasion by Breast Cancer and Mammary Epithelial Cells
Cancer Res., December 1, 2004; 64(23): 8674 - 8681.
[Abstract] [Full Text] [PDF]

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 CROBMHome page
P.N.R. Nair
PATHOGENESIS OF APICAL PERIODONTITIS AND THE CAUSES OF ENDODONTIC FAILURES
Critical Reviews in Oral Biology & Medicine, November 1, 2004; 15(6): 348 - 381.
[Abstract] [Full Text] [PDF]

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 Hum Mol GenetHome page
H. Wang, S. Parry, G. Macones, M. D. Sammel, P. E. Ferrand, H. Kuivaniemi, G. Tromp, I. Halder, M. D. Shriver, R. Romero, et al.
Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM)
Hum. Mol. Genet., November 1, 2004; 13(21): 2659 - 2669.
[Abstract] [Full Text] [PDF]

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 J. Immunol.Home page
A. Ray, D. Kumar, A. Shakya, C. R. Brown, J. L. Cook, and B. K. Ray
Serum Amyloid A-Activating Factor-1 (SAF-1) Transgenic Mice Are Prone to Develop a Severe Form of Inflammation-Induced Arthritis
J. Immunol., October 1, 2004; 173(7): 4684 - 4691.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
Y. Kong, R. Poon, P. Nadesan, T. Di Muccio, R. Fodde, R. Khokha, and B. A. Alman
Matrix Metalloproteinase Activity Modulates Tumor Size, Cell Motility, and Cell Invasiveness in Murine Aggressive Fibromatosis
Cancer Res., August 15, 2004; 64(16): 5795 - 5803.
[Abstract] [Full Text] [PDF]

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 Arterioscler. Thromb. Vasc. Bio.Home page
T. L. Medley, T. J. Cole, A. M. Dart, C. D. Gatzka, and B. A. Kingwell
Matrix Metalloproteinase-9 Genotype Influences Large Artery Stiffness Through Effects on Aortic Gene and Protein Expression
Arterioscler Thromb Vasc Biol, August 1, 2004; 24(8): 1479 - 1484.
[Abstract] [Full Text] [PDF]

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 Biol. Reprod.Home page
S. Campbell, J. Rowe, C.J. Jackson, and E.D.M. Gallery
Interaction of Cocultured Decidual Endothelial Cells and Cytotrophoblasts in Preeclampsia
Biol Reprod, July 1, 2004; 71(1): 244 - 252.
[Abstract] [Full Text] [PDF]

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 Am J Sports MedHome page
I. K. Y. Lo, L. L. Marchuk, R. Hollinshead, D. A. Hart, and C. B. Frank
Matrix Metalloproteinase and Tissue Inhibitor of Matrix Metalloproteinase mRNA Levels Are Specifically Altered in Torn Rotator Cuff Tendons
Am. J. Sports Med., July 1, 2004; 32(5): 1223 - 1229.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
C.-M. Yang, C.-S. Chien, C.-C. Yao, L.-D. Hsiao, Y.-C. Huang, and C. B. Wu
Mechanical Strain Induces Collagenase-3 (MMP-13) Expression in MC3T3-E1 Osteoblastic Cells
J. Biol. Chem., May 21, 2004; 279(21): 22158 - 22165.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
P. Wang, X. Wang, and D. Pei
Mint-3 Regulates the Retrieval of the Internalized Membrane-type Matrix Metalloproteinase, MT5-MMP, to the Plasma Membrane by Binding to Its Carboxyl End Motif EWV
J. Biol. Chem., May 7, 2004; 279(19): 20461 - 20470.
[Abstract] [Full Text] [PDF]

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 Eur Respir JHome page
K. Kanai, K. Asano, T. Hisamitsu, and H. Suzaki
Suppression of matrix metalloproteinase production from nasal fibroblasts by macrolide antibiotics in vitro
Eur. Respir. J., May 1, 2004; 23(5): 671 - 678.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
J. Cao, P. Kozarekar, M. Pavlaki, C. Chiarelli, W. F. Bahou, and S. Zucker
Distinct Roles for the Catalytic and Hemopexin Domains of Membrane Type 1-Matrix Metalloproteinase in Substrate Degradation and Cell Migration
J. Biol. Chem., April 2, 2004; 279(14): 14129 - 14139.
[Abstract] [Full Text] [PDF]

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 ThoraxHome page
O Prause, S Bozinovski, G P Anderson, and A Linden
Increased matrix metalloproteinase-9 concentration and activity after stimulation with interleukin-17 in mouse airways
Thorax, April 1, 2004; 59(4): 313 - 317.
[Abstract] [Full Text] [PDF]

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 J AndrolHome page
M. J. Wilson, A. Jiang, C. Wiehr, X. Wang, A. A. Sinha, and D. Pei
Limited Processing of Pro-Matrix Metalloprotease-2 (Gelatinase A) Overexpressed by Transfection in PC-3 Human Prostate Tumor Cells: Association With Restricted Cell Surface Localization of Membrane-Type Matrix Metalloproteinase-1
J Androl, March 1, 2004; 25(2): 274 - 285.
[Abstract] [Full Text] [PDF]

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 Eur Heart JHome page
P. Hoppmann, W. Koch, A. Schomig, and A. Kastrati
The 5A/6A polymorphism of the stromelysin-1 gene and restenosis after percutaneous coronary interventions
Eur. Heart J., February 2, 2004; 25(4): 335 - 341.
[Abstract] [Full Text] [PDF]

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 Reproductive SciencesHome page
S. J. Merchant, I. P. Crocker, P. N. Baker, D. Tansinda, S. T. Davidge, and L. J. Guilberg
Matrix Metalloproteinase Release From Placental Explants of Pregnancies Complicated by Intrauterine Growth Restriction
Reproductive Sciences, February 1, 2004; 11(2): 97 - 103.
[Abstract] [PDF]

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 BloodHome page
L. M. Pelus, H. Bian, A. G. King, and S. Fukuda
Neutrophil-derived MMP-9 mediates synergistic mobilization of hematopoietic stem and progenitor cells by the combination of G-CSF and the chemokines GRO{beta}/CXCL2 and GRO{beta}T /CXCL2{Delta}4
Blood, January 1, 2004; 103(1): 110 - 119.
[Abstract] [Full Text] [PDF]

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 EndocrinologyHome page
Z. Strakova, M. Szmidt, S. Srisuparp, and A. T. Fazleabas
Inhibition of Matrix Metalloproteinases Prevents the Synthesis of Insulin-Like Growth Factor Binding Protein-1 during Decidualization in the Baboon
Endocrinology, December 1, 2003; 144(12): 5339 - 5346.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
E. L. Martin, B. Z. Moyer, M. C. Pape, B. Starcher, K. J. Leco, and R. A. W. Veldhuizen
Negative impact of tissue inhibitor of metalloproteinase-3 null mutation on lung structure and function in response to sepsis
Am J Physiol Lung Cell Mol Physiol, December 1, 2003; 285(6): L1222 - L1232.
[Abstract] [Full Text] [PDF]

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 Am. J. Pathol.Home page
J. T. Daniels, G. S. Schultz, T. D. Blalock, Q. Garrett, G. R. Grotendorst, N. M. Dean, and P. T. Khaw
Mediation of Transforming Growth Factor-{beta}1-Stimulated Matrix Contraction by Fibroblasts: A Role for Connective Tissue Growth Factor in Contractile Scarring
Am. J. Pathol., November 1, 2003; 163(5): 2043 - 2052.
[Abstract] [Full Text] [PDF]

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 Mol. Biol. CellHome page
T. Sadowski, S. Dietrich, F. Koschinsky, and R. Sedlacek
Matrix Metalloproteinase 19 Regulates Insulin-like Growth Factor-mediated Proliferation, Migration, and Adhesion in Human Keratinocytes through Proteolysis of Insulin-like Growth Factor Binding Protein-3
Mol. Biol. Cell, November 1, 2003; 14(11): 4569 - 4580.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
K. Endo, T. Takino, H. Miyamori, H. Kinsen, T. Yoshizaki, M. Furukawa, and H. Sato
Cleavage of Syndecan-1 by Membrane Type Matrix Metalloproteinase-1 Stimulates Cell Migration
J. Biol. Chem., October 17, 2003; 278(42): 40764 - 40770.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
J. Nie and D. Pei
Direct Activation of Pro-Matrix Metalloproteinase-2 by Leukolysin/Membrane-type 6 Matrix Metalloproteinase/Matrix Metalloproteinase 25 at the Asn109-Tyr Bond
Cancer Res., October 15, 2003; 63(20): 6758 - 6762.
[Abstract] [Full Text] [PDF]

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 Biol. Reprod.Home page
F. Goffin, C. Munaut, F. Frankenne, S. Perrier d'Hauterive, A. Beliard, V. Fridman, P. Nervo, A. Colige, and J.-M. Foidart
Expression Pattern of Metalloproteinases and Tissue Inhibitors of Matrix-Metalloproteinases in Cycling Human Endometrium
Biol Reprod, September 1, 2003; 69(3): 976 - 984.
[Abstract] [Full Text] [PDF]

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 JCBHome page
Y. Torrente, G. Camirand, F. Pisati, M. Belicchi, B. Rossi, F. Colombo, M. El Fahime, N. J. Caron, A. C. Issekutz, G. Constantin, et al.
Identification of a putative pathway for the muscle homing of stem cells in a muscular dystrophy model
J. Cell Biol., August 4, 2003; 162(3): 511 - 520.
[Abstract] [Full Text] [PDF]

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 Endocr. Rev.Home page
T. E. Curry Jr. and K. G. Osteen
The Matrix Metalloproteinase System: Changes, Regulation, and Impact throughout the Ovarian and Uterine Reproductive Cycle
Endocr. Rev., August 1, 2003; 24(4): 428 - 465.
[Abstract] [Full Text] [PDF]

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 JDRHome page
I. Takahashi, M. Nishimura, K. Onodera, J.-W. Bae, H. Mitani, M. Okazaki, Y. Sasano, and H. Mitani
Expression of MMP-8 and MMP-13 Genes in the Periodontal Ligament during Tooth Movement in Rats
Journal of Dental Research, August 1, 2003; 82(8): 646 - 651.
[Abstract] [Full Text] [PDF]

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 JDRHome page
F.R. Tay, M. Hashimoto, D.H. Pashley, M.C. Peters, S.C.N. Lai, C.K.Y. Yiu, and C. Cheong
Aging Affects Two Modes of Nanoleakage Expression in Bonded Dentin
Journal of Dental Research, July 1, 2003; 82(7): 537 - 541.
[Abstract] [Full Text] [PDF]