Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Critical Reviews in Oral Biology & Medicine
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Ramasubbu, N.
Right arrow Articles by Levine, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?
4(3):363-370 (1993)     Crit Rev Oral Biol Med
© 1993 SAGE Publications

Structural Characteristics of Human Salivary Statherin: A Model for Boundary Lubrication at the Enamel Surface

Narayanan Ramasubbu

Department of Oral Biology, Dental Research Institute, School of Dental Medicine, State University of New York at Buffalo, Buffalo, NY 14214

Leonard M. Thomas

Department of Oral Biology, Dental Research Institute, School of Dental Medicine, State University of New York at Buffalo, Buffalo, NY 14214, Also at Department of Biophysics, Roswell Park Cancer Institute, Elm Street, Buffalo NY 14263

Krishna K. Bhandary

Department of Oral Biology, Dental Research Institute, School of Dental Medicine, State University of New York at Buffalo, Buffalo, NY 14214

Michael J. Levine

Department of Oral Biology, Dental Research Institute, School of Dental Medicine, State University of New York at Buffalo, Buffalo, NY 14214

A three-dimensional structural model for salivary statherin in aqueous phase has been developed using structure prediction, circular dichroism, molecular modeling, and mechanics. The relevant structural features of statherin are N-terminal helix segment connected to a long poly-L-proline type II segment, which is followed by a short extended structure. Using this model, the hydroxyapatite binding ability of statherin has been explained. The hydroxyapatite binding region is comprised of the N-terminal acidic residues (Asp-pSer-pSer-Glu-Glu) and Glu-26, which are clustered together in space. Partial conformational unfolding and oriented aggregation of several statherin molecules at the enamel surface provides an amphipathic film that is responsible for the boundary lubrication exhibited by statherin.

Key Words: statherin • molecular modeling • circular dichroism • lubrication • conformational unfolding.

Critical Reviews in Oral Biology & Medicine, Vol. 4, No. 3, 363-370 (1993)
DOI: 10.1177/10454411930040031501
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 MicrobiologyHome page
S. Sekine, K. Kataoka, M. Tanaka, H. Nagata, T. Kawakami, K. Akaji, S. Aimoto, and S. Shizukuishi
Active domains of salivary statherin on apatitic surfaces for binding to Fusobacterium nucleatum cells
Microbiology, July 1, 2004; 150(7): 2373 - 2379.
[Abstract] [Full Text] [PDF]

Home page
 CROBMHome page
P. S. Stayton, G. P. Drobny, W. J. Shaw, J. R. Long, and M. Gilbert
MOLECULAR RECOGNITION AT THE PROTEIN-HYDROXYAPATITE INTERFACE
Critical Reviews in Oral Biology & Medicine, September 1, 2003; 14(5): 370 - 376.
[Abstract] [Full Text] [PDF]

Home page
 JDRHome page
I. lontcheva, F.G. Oppenheim, G.D. Offner, and R.F. Troxler
Molecular Mapping of Statherin- and Histatin-binding Domains in Human Salivary Mucin MG1 (MUC5B) by the Yeast Two-hybrid System
Journal of Dental Research, February 1, 2000; 79(2): 732 - 739.
[Abstract] [PDF]

Home page
 Microbiol. Mol. Biol. Rev.Home page
R. J. Lamont and H. F. Jenkinson
Life Below the Gum Line: Pathogenic Mechanisms of Porphyromonas gingivalis
Microbiol. Mol. Biol. Rev., December 1, 1998; 62(4): 1244 - 1263.
[Abstract] [Full Text] [PDF]

Home page
 CROBMHome page
W.F. Liljemark and C. Bloomquist
Human Oral Microbial Ecology and Dental Caries and Periodontal Diseases
Critical Reviews in Oral Biology & Medicine, January 1, 1996; 7(2): 180 - 198.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Gilbert, W. J. Shaw, J. R. Long, K. Nelson, G. P. Drobny, C. M. Giachelli, and P. S. Stayton
Chimeric Peptides of Statherin and Osteopontin That Bind Hydroxyapatite and Mediate Cell Adhesion
J. Biol. Chem., May 19, 2000; 275(21): 16213 - 16218.
[Abstract] [Full Text] [PDF]