This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Baum, B. J. Articles by Ambudkar, I. S. Search for Related Content PubMed PubMed Citation Social Bookmarking                         What's this?

Signaling Mechanisms That Regulate Saliva Formation

Clinical Investigations and Patient Care Branch, National Institute of Dental Research, National Institutes of Health, Building 10, Room 1 N-113, Bethesda, MD 20892

Yanshan Dai

Clinical Investigations and Patient Care Branch, National Institute of Dental Research, National Institutes of Health, Building 10, Room 1 N-113, Bethesda, MD 20892

Yukiharu Hiramatsu

Clinical Investigations and Patient Care Branch, National Institute of Dental Research, National Institutes of Health, Building 10, Room 1 N-113, Bethesda, MD 20892

Valerie J. Horn

Clinical Investigations and Patient Care Branch, National Institute of Dental Research, National Institutes of Health, Building 10, Room 1 N-113, Bethesda, MD 20892

Indu S. Ambudkar

Clinical Investigations and Patient Care Branch, National Institute of Dental Research, National Institutes of Health, Building 10, Room 1 N-113, Bethesda, MD 20892

The precipitating event in the formation of saliva is the binding of neurotransmitter molecules to cell surface receptor proteins. The principal neurotransmitters involved are acetylcholine and norepinephrine that bind, respectively, to muscarinic-cholinergic, and a- and β-adrenergic receptors. The transduction of the extracellular signal requires an integral membrane protein capable of binding GTP, a G protein, that specifically interacts with the receptor. The components of G protein transduction systems are fairly well studied, but the pathways by which signals are routed are just being recognized. Delineation of such routing pathways is essential to understanding the regulation of saliva formation.

Key Words: neurotransmitter • G proteins • receptors • signal transduction • salivary glands.

Critical Reviews in Oral Biology & Medicine, Vol. 4, No. 3, 379-384 (1993)
DOI: 10.1177/10454411930040031701


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				D. A. Brown, J. E. Melvin, and D. I. Yule Critical role for NHE1 in intracellular pH regulation in pancreatic acinar cells Am J Physiol Gastrointest Liver Physiol, November 1, 2003; 285(5): G804 - G812. [Abstract] [Full Text] [PDF]

				E. Kaufman and I. B. Lamster THE DIAGNOSTIC APPLICATIONS OF SALIVA-- A REVIEW Critical Reviews in Oral Biology & Medicine, March 1, 2002; 13(2): 197 - 212. [Abstract] [Full Text] [PDF]

				P. G. Sawiris and C. O. Enwonwu Ascorbate Deficiency Impairs the Muscarinic-Cholinergic and {beta}-Adrenergic Receptor Signaling Systems in the Guinea Pig Submandibular Salivary Gland J. Nutr., December 1, 2000; 130(12): 2876 - 2882. [Abstract] [Full Text] [PDF]

				J. R. Martinez Developmental Aspects of Fluid and Electrolyte Secretion in Salivary Glands Critical Reviews in Oral Biology & Medicine, January 1, 1994; 5(3): 281 - 290. [Abstract] [Full Text] [PDF]