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Critical Reviews in Oral Biology & Medicine
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4(3):443-448 (1993)     Crit Rev Oral Biol Med
© 1993 SAGE Publications

Rat Submandibular and Parotid Protein Phosphorylation and Exocytosis: Effect of Site-Selective cAMP Analogs

David O. Quissell

University of Colorado Health Sciences Center, School of Dentistry, Department of Basic Sciences and Oral Research, 4200 East 9th Ave, Box C-286, Denver, CO 80262

Katherine A. Barzen

University of Colorado Health Sciences Center, School of Dentistry, Department of Basic Sciences and Oral Research, 4200 East 9th Ave, Box C-286, Denver, CO 80262

Lynn M. Deisher

University of Colorado Health Sciences Center, School of Dentistry, Department of Basic Sciences and Oral Research, 4200 East 9th Ave, Box C-286, Denver, CO 80262

A series of cAMP analogs that have different specificities for the two different binding sites on the regulatory subunit of type I and type n cAMP-dependent protein kinase (PKA) were used to determine whether selective activation of type I or type II PKA could link either or both isozyme forms of PKA with exocytosis and specific protein phosphorylation in salivary gland cells. Using dispersed rat submandibular or parotid cells, selective activation of either type I or type II resulted in a synergistic response for both rat submandibular mucin and parotid amylase secretion and the phosphorylation of a 26-kDa integral membrane phosphoprotein. These data suggest that the activation of either isozyme of PKA can elicit cellular exocytosis and specific protein phosphorylation in both of these cell types.

Key Words: cyclic AMP • cAMP-dependent protein kinase • parotid • submandibular • exocytosis • cyclic AMP analogues.

Critical Reviews in Oral Biology & Medicine, Vol. 4, No. 3, 443-448 (1993)
DOI: 10.1177/10454411930040032601
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