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Critical Reviews in Oral Biology & Medicine
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GENETICALLY ALTERED MOUSE MODELS: THE GOOD, THE BAD, AND THE UGLY

Tamizchelvi Thyagarajan, Satish Totey*, Mary Jo S. Danton and Ashok B. Kulkarni**

Functional Genomics Unit and Gene Targeting Facility, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30, Room 527, 30 Convent Drive, Bethesda, MD 20892;


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  		Figure. Strategy for generation of dTGF-β1 mice and gross tooth abnormalities in these mice. (a) Schematic representation of the TGF-β1 transgenic construct. The transgenic construct was constructed by fusion of a 6-kb dentin sialophosphoprotein (dspp) upstream regulatory sequence with active porcine TGF-β1 cDNA in which Cys223 and Cys225 codons are replaced with serine codons. (b) Normal maxillary and mandibular incisors in wild-type mice. (c) Loss of maxillary incisors (arrowhead,) and discolored and fractured mandibular incisors (arrows) in dTGF-β1 mice. (d) Normal opacity in the craniofacial region of 15-day-old wild-type mice as measured by radiographic analysis. (e) Significantly reduced opacity in the incisors (arrows) and molars (arrowheads) of dTGF-β1 mice. From Thyagarajan et al.(2001). With the permission of the Journal of Biological Chemistry.

 

Critical Reviews in Oral Biology & Medicine, Vol. 14, No. 3, 154-174 (2003)
DOI: 10.1177/154411130301400302
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