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Critical Reviews in Oral Biology & Medicine
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GENOMICS OF ORAL BACTERIA

Margaret J. Duncan

Department of Molecular Genetics, The Forsyth Institute, 140 Fenway, Boston, MA 02115, USA; mduncan{at}forsyth.org


Figure 1
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  		Figure 1. The four phases of a whole-genome sequencing project. From Fraser et al. (2000); reprinted with permission.

 

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  		Figure 2. Putative pathogenicity islands in the P. gingivalis genome. PG numbers are given for the first and last genes in each region. The paralogous regions are approximately 28 and 18 kb. Functional assignments are conditional and were obtained from the TIGR and LANL annotations.

 

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  		Figure 3. Leucine-rich repeats in putative surface proteins of oral bacteria. (A) The repeat region in BspA from B. forsythus. The consensus sequence was calculated such that residues that occur in more than 50% of the repeats are given as a capital letter in the single-letter amino acid code; those that occur in 100% of the repeats are also shown in bold. Residues that occur in less than 50% of the repeats but show some conservation are denoted with a small letter. BspA contains a lipoprotein attachment motif shown in bold in the third repeat. BspA-like proteins were found in the genomes of B. fragilis, T. denticola, and P. intermedia. (B) The repeat region of the internalin-like protein of P. gingivalis. The consensus sequence was derived as described above. The protein contains a lipoprotein attachment motif in the C-terminus (not shown). Internalin-like proteins were found in the genome of P. intermedia.

 

Critical Reviews in Oral Biology & Medicine, Vol. 14, No. 3, 175-187 (2003)
DOI: 10.1177/154411130301400303
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