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THE ROLE OF TGF-β IN EPITHELIAL MALIGNANCY AND ITS RELEVANCE TO THE PATHOGENESIS OF ORAL CANCER (PART II)

Department of Oral and Dental Science, Division of Oral Medicine, Pathology and Microbiology, Bristol Dental Hospital and School, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, United Kingdom;

View larger version (53K): [in this window] [in a new window]   Figure. The role of TGF-β in epithelial carcinogenesis. In normal epithelial cells with an intact TGF-β signaling pathway, TGF-β functions as a tumor suppressor by inhibiting cell proliferation and enhancing apoptosis, together with the regulation of replicative senescence and suppression of telomerase. During multi-step tumorigenesis, cells acquire defects in the TGF-β signaling pathway, which abrogates or diminishes the responses of the tumor cells to TGF-β, and oncogene signaling may also alter the cellular response to TGF-β. Some late-stage tumors are also known to overproduce TGF-β. Consequently, TGF-β shifts from a suppressor to a promoter of tumor progression, by increasing angiogenesis, enhancing motility/invasion, and, at times, inducing an epithelial-mesenchymal transdifferentiation.

Critical Reviews in Oral Biology & Medicine, Vol. 15, No. 6, 337-347 (2004)
DOI: 10.1177/154411130401500603


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